A review in the respected journal, Nature reports that “extracorporeal low-intensity shockwave treatment (LIST) of the penis is a promising treatment in men with severe erectile dysfunction (ED) not responsive to phosphodiesterase 5 (PDE5) inhibitors.” The therapy has been shown to improve nerve-stimulated erectile function and increase the endothelial content of penile tissue in a diabetic rat model.
It reports on a study published in the Journal of Urology December 2015 by Kitrey, N. D. et al. on Penile low intensity shockwave treatment showing a shift of PDE5i non-responders to responders in a double blind sham-controlled study of 58 patients. After treatment, 20 patients (54.1%) in the LIST group achieved erection hardness adequate for penetration compared with no patients in the sham group. A month after sham treatment, patients in the sham group were offered active treatment; 16 of these patients completed treatment and nine of them (56.3%) achieved erections.
The summary in Nature, Shockwaves for erectile dysfunction, can be accessed here (with subscription)
The article, Penile low-intensity shockwave treatment is able to shift PDE5i non-responders to responders: A double-blind sham-controlled study, in the Journal of Urology can be accessed here (with subscription)